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Novel Mechanisms for Cell-to-Cell Communication in Fish

Novel Mechanisms for Cell-to-Cell Communication in Fish

The current project aims to describe the phenomenon of mitochondrial exchange in salmon and zebra fish - how this occur, analysis of transcriptomic and proteomic responses during mitochondrial exchange, and examine this phenomenon in vivo in a zebrafish model system. Mitochondria generate most of the chemical energy needed to fuel the cells biochemical reactions. It is clear that mitochondria also participate in innate defence against pathogens (viruses and bacteria) and are also able to produce signalling molecules central in the pathogen defence. It is also known that mitochondria can be transferred from one cell to another following cellular stress and tissue damage. How this transfer occurs is not clear yet, though there are indications that cells secrete vesicles and forms tunnels which may be a way of transfer. The project aims to characterise mitochondrial exchange by stressing cells by immunostimulants and nano plastics. Characterisation of mitochondrial exchange will be observed using high-end nanoscopy, whereas the cellular responses will be assessed by proteomic and transcriptomic analysis. The project will produce knowledge how cell may communicate with each other, what stressors that induce this phenomenon, and the biological impact this has on fish.

Contact

Arinze Stanley Okoli

Senior Researcher - Tromsø
arok@norceresearch.no
+47 56 10 78 85

Project facts

Name

Novel mechanisms for cell-to-cell communication in fish

Status

Active

Duration

01.12.21 - 30.11.27

Location

Tromsø

Research areas

Research group

Funding

Kunnskapsdepartementet

Prosjekteier

UiT Norges arktiske universitet

Project members

Roy Ambli Dalmo
Zuobing Zhang
Sigrun Lange
Hong Mao
Kim Præbel
Shripathi Bhat
Ida Sundvor Opstad
Deanna Wolfson
Balpreet Singh Ahluwalia

Samarbeidspartnere

NORCE, Shanxi Normal University, University of Westminster,