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Pål Puntervoll

Pål Puntervoll

Senior Researcher

papu@norceresearch.no
+47 56 10 74 36
Nygårdsgaten 112, 5008 Bergen, Norway

I'm a molecular biologist with extensive experience in bioinformatics. Currently, my research focuses primarily on the identification and development of new enzymes for industrial applications. This activity adresses the needs of a growing Norwegian biotechnology sector.

In addition, a main research activity since 2009 has been the development of a vaccine component targeting childhood and traveller's diarrhoea. This work focused on detoxifying the heat-stable toxin of enterotoxigenic Escherichia coli and making it immunogenic by coupling it to a protein carrier. This work has resulted in several publications and two patents.

My core competence is the study of protein structure and function. Over the years, I have gained solid experience in the experimental study of proteins and enzymes, which includes recombinant expression and purification, peptide/protein/enzyme engineering, and functional studies. My career in bioinformatics started by contributing to the development of a bioinformatics resource for short linear motifs that provide a wide range of functionality to proteins. As member of the service group of the Computational Biology Unit in Bergen, I expanded my competence in several directions and headed a project on the development of an e-infrastructure for the life sciences.

Pål Puntervoll

Division

Climate & Environment

Research Groups

Marin bioteknologi

More information about Pål Puntervoll

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Projects
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Publications
A ShK-like Domain from Steinernema carpocapsae with Bioinsecticidal Potential – Toxins 2022
Vaccine Candidate Double Mutant Variants of Enterotoxigenic Escherichia coli Heat-Stable Toxin – Vaccines 2022
Antiviral Potential of Algal Metabolites—A Comprehensive Review – Marine Drugs 2021
Two-step functional screen on multiple proteinaceous substrates reveals temperature-robust proteases with a broad-substrate range – Applied Microbiology and Biotechnology 2021
Fragment exchange (FX) plasmid tools for CRISPR/Cas9-mediated gene integration and protease production in Bacillus subtilis – Applied and Environmental Microbiology 2020
Use of flavin containing monooxygenases for conversion of trimethylamine in salmon protein hydrolysates – Applied and Environmental Microbiology 2020
Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice – Vaccine 2019
Immunizations with enterotoxigenic Escherichia coli heat-stable toxin conjugates engender toxin-neutralizing antibodies in mice that also cross-react with guanylin and uroguanylin – Infection and Immunity 2019
Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin – Human Vaccines & Immunotherapeutics 2018
Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition – Proteins: Structure, Function, and Bioinformatics 2018
Purification and characterization of native and vaccine candidate mutant enterotoxigenic escherichia coli heat-stable toxins – Toxins 2018
Independent losses of a xenobiotic receptor across teleost evolution – Scientific Reports 2018
SBMLmod: a Python-based web application and web service for efficient data integration and model simulation – BMC Bioinformatics 2017
Towards rational design of a toxoid vaccine against the heatstable toxin of Escherichia coli – Infection and Immunity 2016
A rapid solubility-optimized screening procedure for recombinant subtilisins in E. coli – Journal of Biotechnology 2016
Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin – Infection and Immunity 2014
Pipelined data-flow delegated orchestration for data-intensive eScience workflows – International Journal of Web Information Systems 2013
Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data – Journal of Biological Chemistry 2013
Effect of substrate competition in kinetic models of metabolic networks – FEBS Letters 2013
Genomic sequence and analysis of EhV-99B1, a new coccolithovirus from the Norwegian fjords – Intervirology 2013
NAD(+) biosynthesis and salvage - a phylogenetic perspective – The FEBS Journal 2012
Linkage-disequilibrium-based binning affects the interpretation of GWASs – American Journal of Human Genetics 2012
Mass spectrometric analyses of microsomal cytochrome P450 isozymes isolated from beta-naphthoflavone-treated Atlantic cod (Gadus morhua) liver reveal insights into the cod CYPome – Aquatic Toxicology 2012
Direct data transfer between SOAP web services in orchestration – 2012
Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153 – Aquatic Toxicology 2011
Data partitioning enables the use of standard SOAP Web Services in genome-scale workflows – Journal of Integrative Bioinformatics (JIB) 2011
Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia – Journal of Proteomics 2011
Responses in the brain proteome of Atlantic cod (Gadus morhua) exposed to methylmercury – Aquatic Toxicology 2010
Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers – Molecular Cancer 2010
Heat-stable enterotoxin of enterotoxigenic escherichia coli as a vaccine target – Infection and Immunity 2010
ELM: the status of the 2010 eukaryotic linear motif resource – Nucleic Acids Research (NAR) 2010
BioXSD: the common data-exchange format for everyday bioinformatics web services – Bioinformatics 2010
Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress – The FEBS Journal 2008
The major outer membrane protein of Fusobacterium nucleatum (FomA) folds and inserts into lipid bilayers via parallel folding pathways – Journal of Molecular Biology (JMB) 2006
Identification of a copper-repressible cytochrome c peroxidase of Methylococcus capsulatus (Bath); a member of a novel group of the bacterial di-heme cytochrome c peroxidase family of proteins – The FEBS Journal 2005
Nomenclatures for protein modules and their cognate motifs – 2004
ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins – Nucleic Acids Research (NAR) 2003
Structural characterisation of the fusobacterial non-specific porin FomA suggests a 14-stranded topology, unlike the classical porins – Microbiology 2002
Topological investigations on the FomA porin from Fusobacterium nucleatum and identification of the constriction loop L6 – Microbiology 2001
Cloning of the fom A gene encoding the major outer membrane porin of Fusobacterium nucleatum – Microbiol Pathogenesis 1996
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